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pentobarbital will reduce the extent or effect of itraconazole by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unfamiliar.pentobarbital will lessen the level or influence of glecaprevir/pibrentasvir by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will lessen the level or influence of fosaprepitant b